Drug interactions
Apalutamide + Paricalcitol
Severity: Minor
Apalutamide and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may modestly reduce paricalcitol exposure. The clinical effect is likely small and detectable through routine PTH monitoring.
What this interaction means in plain words
Apalutamide and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Paricalcitol belongs to Musculoskeletal.
Why it happens
Apalutamide induces CYP3A4, which contributes to paricalcitol metabolism.
What to do
Monitor intact PTH, calcium and phosphorus and adjust the paricalcitol dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Apalutamide with Paricalcitol?
MediHelp rates the interaction as minor. Apalutamide and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide may modestly reduce paricalcitol exposure. The clinical effect is likely small and detectable through routine PTH monitoring.
How serious is the interaction between Apalutamide and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intact PTH, calcium and phosphorus and adjust the paricalcitol dose as needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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