Drug interactions
Cholestyramine + Sarecycline
Severity: Moderate
Cholestyramine and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine may bind sarecycline in the gut and reduce its absorption, possibly weakening acne treatment response.
What this interaction means in plain words
Cholestyramine and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Binding of sarecycline to the resin in the gut reduces absorption.
What to do
Take sarecycline at least 2 hours before or after cholestyramine, and monitor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Cholestyramine with Sarecycline?
MediHelp rates the interaction as moderate. Cholestyramine and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine may bind sarecycline in the gut and reduce its absorption, possibly weakening acne treatment response.
How serious is the interaction between Cholestyramine and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take sarecycline at least 2 hours before or after cholestyramine, and monitor response.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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