Drug interactions
Cholestyramine + Tinidazole
Severity: Moderate
Cholestyramine and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine is a bile acid sequestrant that can bind other oral drugs in the gut and reduce their absorption. Tinidazole absorption may be reduced, which could lower its effectiveness.
What this interaction means in plain words
Cholestyramine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
Why it happens
Cholestyramine binds tinidazole in the gastrointestinal tract, reducing its oral bioavailability.
What to do
Give tinidazole at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Tinidazole?
MediHelp rates the interaction as moderate. Cholestyramine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine is a bile acid sequestrant that can bind other oral drugs in the gut and reduce their absorption. Tinidazole absorption may be reduced, which could lower its effectiveness.
How serious is the interaction between Cholestyramine and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give tinidazole at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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