Drug interactions
Cholic acid + Loratadine
Severity: Minor
Cholic acid and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholic acid can accumulate in hepatocytes if the bile salt export pump is inhibited, risking liver injury. Loratadine is not a recognized clinically significant BSEP inhibitor, so the interaction is largely theoretical.
What this interaction means in plain words
Cholic acid and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cholic acid belongs to Gastrointestinal Tract; Loratadine belongs to Respiratory.
Why it happens
Theoretical inhibition of the bile salt export pump (BSEP), reducing bile acid elimination.
What to do
Monitor serum transaminases and bilirubin as already required during cholic acid therapy. Reassess the need for loratadine if liver tests worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Loratadine?
MediHelp rates the interaction as minor. Cholic acid and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cholic acid can accumulate in hepatocytes if the bile salt export pump is inhibited, risking liver injury. Loratadine is not a recognized clinically significant BSEP inhibitor, so the interaction is largely theoretical.
How serious is the interaction between Cholic acid and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin as already required during cholic acid therapy. Reassess the need for loratadine if liver tests worsen.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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