Drug interactions
Cholic acid + Ranolazine
Severity: Moderate
Cholic acid and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may inhibit the bile salt export pump, which can lead to accumulation of bile acids in hepatocytes. With cholic acid therapy this may increase the risk of liver injury.
What this interaction means in plain words
Cholic acid and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of the hepatic bile salt export pump (BSEP) reduces bile acid efflux.
What to do
Avoid the combination if possible. If both are needed, monitor serum transaminases and bilirubin regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Ranolazine?
MediHelp rates the interaction as moderate. Cholic acid and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine may inhibit the bile salt export pump, which can lead to accumulation of bile acids in hepatocytes. With cholic acid therapy this may increase the risk of liver injury.
How serious is the interaction between Cholic acid and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are needed, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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