Drug interactions
Choline magnesium trisalicylate + Duloxetine
Severity: Moderate
Choline magnesium trisalicylate and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine impairs platelet serotonin uptake and salicylates inhibit platelet function and can irritate the gastric lining. Together they raise bleeding risk, especially upper GI bleeding. Non-acetylated salicylates have a weaker antiplatelet effect than aspirin, though GI risk remains.
What this interaction means in plain words
Choline magnesium trisalicylate and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis and mucosal injury from SNRI and salicylate.
What to do
Monitor for bleeding signs and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Duloxetine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine impairs platelet serotonin uptake and salicylates inhibit platelet function and can irritate the gastric lining. Together they raise bleeding risk, especially upper GI bleeding. Non-acetylated salicylates have a weaker antiplatelet effect than aspirin, though GI risk remains.
How serious is the interaction between Choline magnesium trisalicylate and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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