Drug interactions
Choline magnesium trisalicylate + Trazodone
Severity: Moderate
Choline magnesium trisalicylate and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants including trazodone impair platelet serotonin uptake and can increase bleeding tendency. Combined with a salicylate that inhibits platelet function and irritates the gastric mucosa, the risk of gastrointestinal bleeding rises.
What this interaction means in plain words
Choline magnesium trisalicylate and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired platelet aggregation from serotonin reuptake inhibition combined with salicylate antiplatelet and mucosal effects.
What to do
Monitor for signs of bleeding such as black stools or bruising, and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Trazodone?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic antidepressants including trazodone impair platelet serotonin uptake and can increase bleeding tendency. Combined with a salicylate that inhibits platelet function and irritates the gastric mucosa, the risk of gastrointestinal bleeding rises.
How serious is the interaction between Choline magnesium trisalicylate and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding such as black stools or bruising, and consider gastroprotection in high-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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