Drug interactions
Choline magnesium trisalicylate + Vortioxetine
Severity: Moderate
Choline magnesium trisalicylate and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates impair platelet function and can irritate the gastric mucosa, and vortioxetine adds platelet dysfunction through serotonin depletion. The combination raises the risk of bleeding, particularly gastrointestinal.
What this interaction means in plain words
Choline magnesium trisalicylate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet and mucosal effects: platelet serotonin depletion plus salicylate-mediated cyclooxygenase inhibition.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Vortioxetine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates impair platelet function and can irritate the gastric mucosa, and vortioxetine adds platelet dysfunction through serotonin depletion. The combination raises the risk of bleeding, particularly gastrointestinal.
How serious is the interaction between Choline magnesium trisalicylate and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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