Drug interactions
Chromium + Tolbutamide
Severity: Minor
Chromium and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chromium supplements may modestly improve insulin sensitivity and add to the effect of tolbutamide. The effect is likely small but hypoglycemia is conceivable.
What this interaction means in plain words
Chromium and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chromium belongs to Gastrointestinal Tract; Tolbutamide belongs to Endocrine.
Why it happens
Possible additive glucose lowering through enhanced insulin action.
What to do
Monitor blood glucose when chromium is started or stopped and adjust tolbutamide if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Chromium
- Chromium + Omadacycline Moderate
- Chromium + Sarecycline Moderate
- Acarbose + Chromium Minor
- Acetylsalicylic acid + Chromium Minor
- Alogliptin-metformin + Chromium Minor
- Alogliptin-pioglitazone + Chromium Minor
Frequently asked questions
Can I take Chromium with Tolbutamide?
MediHelp rates the interaction as minor. Chromium and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chromium supplements may modestly improve insulin sensitivity and add to the effect of tolbutamide. The effect is likely small but hypoglycemia is conceivable.
How serious is the interaction between Chromium and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when chromium is started or stopped and adjust tolbutamide if glucose falls.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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