Drug interactions
Cidofovir + Ioversol
Severity: Contraindicated
Cidofovir and Ioversol: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent capable of causing contrast-associated kidney injury, and cidofovir is a potent proximal tubular toxin. Combined exposure raises the risk of serious renal failure, and cidofovir labeling prohibits concomitant nephrotoxic drugs.
What this interaction means in plain words
Cidofovir and Ioversol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive nephrotoxicity from cidofovir tubular injury and contrast-induced renal vasoconstriction and tubular toxicity.
What to do
Avoid ioversol during cidofovir therapy and for at least 7 days before it; use non-contrast imaging where possible. If unavoidable, ensure hydration and monitor creatinine closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Ioversol?
MediHelp rates the interaction as contraindicated. Cidofovir and Ioversol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ioversol is an iodinated contrast agent capable of causing contrast-associated kidney injury, and cidofovir is a potent proximal tubular toxin. Combined exposure raises the risk of serious renal failure, and cidofovir labeling prohibits concomitant nephrotoxic drugs.
How serious is the interaction between Cidofovir and Ioversol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ioversol during cidofovir therapy and for at least 7 days before it; use non-contrast imaging where possible. If unavoidable, ensure hydration and monitor creatinine closely.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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