Drug interactions
Cidofovir + Methoxyflurane
Severity: Major
Cidofovir and Methoxyflurane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cidofovir causes dose-related proximal tubular nephrotoxicity, and methoxyflurane is a known nephrotoxic anesthetic through fluoride release. Combined exposure could cause serious kidney injury.
What this interaction means in plain words
Cidofovir and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from proximal tubular injury by cidofovir and fluoride metabolites of methoxyflurane.
What to do
Avoid combined use; cidofovir labeling advises against concurrent nephrotoxic agents. If unavoidable, check serum creatinine and urine protein before each cidofovir dose and ensure hydration with probenecid.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Methoxyflurane?
MediHelp rates the interaction as major. Cidofovir and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cidofovir causes dose-related proximal tubular nephrotoxicity, and methoxyflurane is a known nephrotoxic anesthetic through fluoride release. Combined exposure could cause serious kidney injury.
How serious is the interaction between Cidofovir and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use; cidofovir labeling advises against concurrent nephrotoxic agents. If unavoidable, check serum creatinine and urine protein before each cidofovir dose and ensure hydration with probenecid.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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