Drug interactions
Cidofovir + Peramivir
Severity: Moderate
Cidofovir and Peramivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cidofovir is nephrotoxic, and peramivir is eliminated almost exclusively by the kidneys. Reduced renal function from cidofovir may raise peramivir exposure.
What this interaction means in plain words
Cidofovir and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cidofovir-induced renal impairment reducing peramivir clearance.
What to do
Monitor serum creatinine and adjust the peramivir dose to creatinine clearance per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Peramivir?
MediHelp rates the interaction as moderate. Cidofovir and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cidofovir is nephrotoxic, and peramivir is eliminated almost exclusively by the kidneys. Reduced renal function from cidofovir may raise peramivir exposure.
How serious is the interaction between Cidofovir and Peramivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust the peramivir dose to creatinine clearance per labeling.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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