Drug interactions
Cidofovir + Polymyxin b
Severity: Contraindicated
Cidofovir and Polymyxin b: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs injure the renal tubules, and polymyxin B also has neurotoxic effects. Concurrent use greatly increases the risk of acute kidney injury.
What this interaction means in plain words
Cidofovir and Polymyxin b are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cidofovir belongs to Anti Virals; Polymyxin b belongs to Anti Bacterial.
Why it happens
Additive direct tubular nephrotoxicity.
What to do
Avoid the combination, as cidofovir labeling prohibits concurrent nephrotoxins. Use an alternative antibiotic or antiviral, and if unavoidable, monitor creatinine daily.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Polymyxin b
- Colistin + Polymyxin b Contraindicated
- Acyclovir + Polymyxin b Major
- Adefovir + Polymyxin b Major
- Amikacin + Polymyxin b Major
- Amphotericin b + Polymyxin b Major
- Atracurium + Polymyxin b Major
Frequently asked questions
Can I take Cidofovir with Polymyxin b?
MediHelp rates the interaction as contraindicated. Cidofovir and Polymyxin b are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs injure the renal tubules, and polymyxin B also has neurotoxic effects. Concurrent use greatly increases the risk of acute kidney injury.
How serious is the interaction between Cidofovir and Polymyxin b?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as cidofovir labeling prohibits concurrent nephrotoxins. Use an alternative antibiotic or antiviral, and if unavoidable, monitor creatinine daily.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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