Drug interactions
Cidofovir + Streptozocin
Severity: Contraindicated
Cidofovir and Streptozocin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin commonly causes dose-related renal toxicity, which can be severe, and cidofovir is a potent proximal tubular toxin. Together the risk of acute kidney injury is high, and cidofovir labeling prohibits concomitant nephrotoxic agents.
What this interaction means in plain words
Cidofovir and Streptozocin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive nephrotoxicity from cidofovir tubular injury and streptozocin renal tubular toxicity.
What to do
Do not co-administer; stop nephrotoxic agents at least 7 days before starting cidofovir and use an alternative where possible. Monitor creatinine and urine protein closely if sequential use is unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Streptozocin?
MediHelp rates the interaction as contraindicated. Cidofovir and Streptozocin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Streptozocin commonly causes dose-related renal toxicity, which can be severe, and cidofovir is a potent proximal tubular toxin. Together the risk of acute kidney injury is high, and cidofovir labeling prohibits concomitant nephrotoxic agents.
How serious is the interaction between Cidofovir and Streptozocin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop nephrotoxic agents at least 7 days before starting cidofovir and use an alternative where possible. Monitor creatinine and urine protein closely if sequential use is unavoidable.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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