Drug interactions
Cidofovir + Tobramycin inhaled
Severity: Moderate
Cidofovir and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low systemic absorption, so the added renal burden is usually small. However, absorption can be higher with impaired renal function, and cidofovir is strongly nephrotoxic. Systemic aminoglycoside exposure could add to kidney and inner ear toxicity.
What this interaction means in plain words
Cidofovir and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive nephrotoxicity and ototoxicity if systemic tobramycin exposure occurs.
What to do
Monitor serum creatinine and urinalysis before each cidofovir dose and check tobramycin serum levels if renal function declines. Report hearing changes or tinnitus promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Cidofovir and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low systemic absorption, so the added renal burden is usually small. However, absorption can be higher with impaired renal function, and cidofovir is strongly nephrotoxic. Systemic aminoglycoside exposure could add to kidney and inner ear toxicity.
How serious is the interaction between Cidofovir and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urinalysis before each cidofovir dose and check tobramycin serum levels if renal function declines. Report hearing changes or tinnitus promptly.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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