Drug interactions
Cigarette smoking + Duloxetine
Severity: Minor
Cigarette smoking and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces CYP1A2 and lowers duloxetine concentrations, with exposure about one third lower reported in smokers. The effect is generally not clinically important and no dose adjustment is recommended in labeling.
What this interaction means in plain words
Cigarette smoking and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Polycyclic aromatic hydrocarbons in smoke induce CYP1A2, increasing duloxetine clearance.
What to do
No routine dose change is required. Reassess response if the patient starts or stops smoking.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Cigarette smoking with Duloxetine?
MediHelp rates the interaction as minor. Cigarette smoking and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Smoking induces CYP1A2 and lowers duloxetine concentrations, with exposure about one third lower reported in smokers. The effect is generally not clinically important and no dose adjustment is recommended in labeling.
How serious is the interaction between Cigarette smoking and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Reassess response if the patient starts or stops smoking.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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