Drug interactions
Cigarette smoking + Melatonin
Severity: Minor
Cigarette smoking and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobacco smoke induces CYP1A2, which is the main enzyme clearing melatonin. Smokers may have lower melatonin concentrations and a weaker response to a given dose.
What this interaction means in plain words
Cigarette smoking and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP1A2 by polycyclic aromatic hydrocarbons in smoke increases melatonin clearance.
What to do
Titrate melatonin to effect, as a higher dose may be needed; reassess the dose if the patient stops smoking.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Cigarette smoking with Melatonin?
MediHelp rates the interaction as minor. Cigarette smoking and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tobacco smoke induces CYP1A2, which is the main enzyme clearing melatonin. Smokers may have lower melatonin concentrations and a weaker response to a given dose.
How serious is the interaction between Cigarette smoking and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate melatonin to effect, as a higher dose may be needed; reassess the dose if the patient stops smoking.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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