Drug interactions
Cilostazol + Duvelisib
Severity: Moderate
Cilostazol and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a moderate CYP3A4 inhibitor and may raise cilostazol levels, increasing dose-related adverse effects such as headache, palpitations and tachycardia.
What this interaction means in plain words
Cilostazol and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by duvelisib reduces cilostazol clearance.
What to do
Consider reducing cilostazol to 50 mg twice daily while on duvelisib. Monitor heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Cilostazol with Duvelisib?
MediHelp rates the interaction as moderate. Cilostazol and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a moderate CYP3A4 inhibitor and may raise cilostazol levels, increasing dose-related adverse effects such as headache, palpitations and tachycardia.
How serious is the interaction between Cilostazol and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily while on duvelisib. Monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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