Drug interactions
Cilostazol + Lenacapavir
Severity: Moderate
Cilostazol and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor with a long duration of effect after subcutaneous dosing, so cilostazol exposure may increase for months. This raises the risk of headache, tachycardia and palpitations.
What this interaction means in plain words
Cilostazol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Moderate CYP3A4 inhibition by lenacapavir reduces cilostazol clearance.
What to do
Consider reducing cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Cilostazol with Lenacapavir?
MediHelp rates the interaction as moderate. Cilostazol and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor with a long duration of effect after subcutaneous dosing, so cilostazol exposure may increase for months. This raises the risk of headache, tachycardia and palpitations.
How serious is the interaction between Cilostazol and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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