Drug interactions
Cilostazol + Mitotane
Severity: Moderate
Cilostazol and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent enzyme inducer and can markedly lower cilostazol exposure. This may reduce its effect on intermittent claudication symptoms.
What this interaction means in plain words
Cilostazol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolism of cilostazol.
What to do
Monitor for loss of claudication benefit and consider an alternative if response is inadequate. Reassess cilostazol response after mitotane is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Cilostazol with Mitotane?
MediHelp rates the interaction as moderate. Cilostazol and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a potent enzyme inducer and can markedly lower cilostazol exposure. This may reduce its effect on intermittent claudication symptoms.
How serious is the interaction between Cilostazol and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of claudication benefit and consider an alternative if response is inadequate. Reassess cilostazol response after mitotane is started or stopped.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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