Drug interactions
Cilostazol + Rifapentine
Severity: Moderate
Cilostazol and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine can lower cilostazol exposure and reduce its benefit. Induction continues for a time after rifapentine is stopped.
What this interaction means in plain words
Cilostazol and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, accelerating cilostazol metabolism.
What to do
Monitor claudication symptoms and consider an alternative if response is inadequate. Reassess cilostazol dosing when rifapentine ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Cilostazol with Rifapentine?
MediHelp rates the interaction as moderate. Cilostazol and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine can lower cilostazol exposure and reduce its benefit. Induction continues for a time after rifapentine is stopped.
How serious is the interaction between Cilostazol and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms and consider an alternative if response is inadequate. Reassess cilostazol dosing when rifapentine ends.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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