Drug interactions
Cilostazol + Riociguat
Severity: Moderate
Cilostazol and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat stimulates soluble guanylate cyclase and raises cGMP, causing vasodilation. Cilostazol, a PDE3 inhibitor, may add to hypotension, although data on combining it with riociguat are limited.
What this interaction means in plain words
Cilostazol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive vasodilation from soluble guanylate cyclase stimulation and PDE3 inhibition.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Titrate riociguat cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Cilostazol with Riociguat?
MediHelp rates the interaction as moderate. Cilostazol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat stimulates soluble guanylate cyclase and raises cGMP, causing vasodilation. Cilostazol, a PDE3 inhibitor, may add to hypotension, although data on combining it with riociguat are limited.
How serious is the interaction between Cilostazol and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Titrate riociguat cautiously.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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