Drug interactions
Cilostazol + Secobarbital
Severity: Moderate
Cilostazol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is an inducer of hepatic and intestinal CYP3A4 and may lower circulating cilostazol and its active metabolites. This could reduce the improvement in claudication symptoms expected from cilostazol.
What this interaction means in plain words
Cilostazol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolic clearance of cilostazol.
What to do
Monitor claudication response when secobarbital is started or stopped and consider an alternative hypnotic if efficacy is lost. Reassess cilostazol response after the inducer is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Cilostazol with Secobarbital?
MediHelp rates the interaction as moderate. Cilostazol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is an inducer of hepatic and intestinal CYP3A4 and may lower circulating cilostazol and its active metabolites. This could reduce the improvement in claudication symptoms expected from cilostazol.
How serious is the interaction between Cilostazol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication response when secobarbital is started or stopped and consider an alternative hypnotic if efficacy is lost. Reassess cilostazol response after the inducer is withdrawn.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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