Drug interactions
Cilostazol + Sertraline
Severity: Minor
Cilostazol and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak CYP2C19 inhibitor and is unlikely to change cilostazol exposure meaningfully. Both drugs can affect platelet function or bleeding, so additive bleeding risk is a more plausible consideration.
What this interaction means in plain words
Cilostazol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP2C19 inhibition by sertraline; additive antiplatelet effects, since SSRIs deplete platelet serotonin.
What to do
No dose change is routinely required. Monitor for bruising or bleeding and cilostazol adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Cilostazol with Sertraline?
MediHelp rates the interaction as minor. Cilostazol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a weak CYP2C19 inhibitor and is unlikely to change cilostazol exposure meaningfully. Both drugs can affect platelet function or bleeding, so additive bleeding risk is a more plausible consideration.
How serious is the interaction between Cilostazol and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor for bruising or bleeding and cilostazol adverse effects.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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