Drug interactions
Cilostazol + Ticagrelor
Severity: Moderate
Cilostazol and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit platelet function, so combined use may increase bleeding risk. Cilostazol is sometimes combined with antiplatelets in vascular disease.
What this interaction means in plain words
Cilostazol and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects: P2Y12 blockade plus PDE3 inhibition.
What to do
Monitor for bleeding and hemoglobin changes. Use only when the benefit is clear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Ticagrelor?
MediHelp rates the interaction as moderate. Cilostazol and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs inhibit platelet function, so combined use may increase bleeding risk. Cilostazol is sometimes combined with antiplatelets in vascular disease.
How serious is the interaction between Cilostazol and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin changes. Use only when the benefit is clear.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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