Drug interactions
Cilostazol + Verapamil
Severity: Moderate
Cilostazol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase cilostazol exposure, potentially causing headache, tachycardia, palpitations and dizziness. Cilostazol is contraindicated in heart failure, so tachyarrhythmic effects matter.
What this interaction means in plain words
Cilostazol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing cilostazol metabolism.
What to do
Consider reducing the cilostazol dose to 50 mg twice daily with verapamil, as labeling suggests for CYP3A4 inhibitors, and monitor for tachycardia and headache.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Verapamil?
MediHelp rates the interaction as moderate. Cilostazol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase cilostazol exposure, potentially causing headache, tachycardia, palpitations and dizziness. Cilostazol is contraindicated in heart failure, so tachyarrhythmic effects matter.
How serious is the interaction between Cilostazol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cilostazol dose to 50 mg twice daily with verapamil, as labeling suggests for CYP3A4 inhibitors, and monitor for tachycardia and headache.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
