Drug interactions
Cimetidine + Clopidogrel
Severity: Minor
Cimetidine and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine weakly inhibits CYP2C19, which may reduce activation of clopidogrel. Studies showed no meaningful reduction in platelet inhibition, so the clinical impact is likely small.
What this interaction means in plain words
Cimetidine and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Clopidogrel belongs to Cardiovascular.
Why it happens
Weak CYP2C19 inhibition by cimetidine may decrease formation of the active clopidogrel metabolite.
What to do
No change is generally needed; if a gastroprotective agent is required, pantoprazole or famotidine are reasonable choices.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Cimetidine with Clopidogrel?
MediHelp rates the interaction as minor. Cimetidine and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine weakly inhibits CYP2C19, which may reduce activation of clopidogrel. Studies showed no meaningful reduction in platelet inhibition, so the clinical impact is likely small.
How serious is the interaction between Cimetidine and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is generally needed; if a gastroprotective agent is required, pantoprazole or famotidine are reasonable choices.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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