Drug interactions
Cimetidine + Darolutamide
Severity: Minor
Cimetidine and Darolutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, but cimetidine is not an important BCRP substrate, so a meaningful rise in cimetidine exposure is not established. No clinically significant interaction is expected.
What this interaction means in plain words
Cimetidine and Darolutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Darolutamide belongs to Miscellaneous.
Why it happens
Darolutamide BCRP inhibition could theoretically affect cimetidine transport, but this is not well established.
What to do
No specific action is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Cimetidine with Darolutamide?
MediHelp rates the interaction as minor. Cimetidine and Darolutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darolutamide inhibits BCRP, but cimetidine is not an important BCRP substrate, so a meaningful rise in cimetidine exposure is not established. No clinically significant interaction is expected.
How serious is the interaction between Cimetidine and Darolutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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