Drug interactions
Cimetidine + Isavuconazonium
Severity: Minor
Cimetidine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a CYP3A4 substrate, and cimetidine is a weak CYP3A4 inhibitor. Exposure to isavuconazole may rise slightly, but the effect is generally small.
What this interaction means in plain words
Cimetidine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of isavuconazole by cimetidine.
What to do
No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as hepatic enzyme elevation or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Cimetidine with Isavuconazonium?
MediHelp rates the interaction as minor. Cimetidine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole, the active moiety, is a CYP3A4 substrate, and cimetidine is a weak CYP3A4 inhibitor. Exposure to isavuconazole may rise slightly, but the effect is generally small.
How serious is the interaction between Cimetidine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as hepatic enzyme elevation or gastrointestinal upset.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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