Drug interactions
Cimetidine + Lemborexant
Severity: Moderate
Cimetidine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor and can raise lemborexant exposure. This increases the risk of next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Cimetidine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Lemborexant belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces the metabolic clearance of lemborexant.
What to do
Limit the lemborexant dose to the lower recommended maximum with weak CYP3A4 inhibitors and counsel patients about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Cimetidine with Lemborexant?
MediHelp rates the interaction as moderate. Cimetidine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a weak CYP3A4 inhibitor and can raise lemborexant exposure. This increases the risk of next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Cimetidine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lemborexant dose to the lower recommended maximum with weak CYP3A4 inhibitors and counsel patients about next-day drowsiness.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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