Drug interactions
Cimetidine + Leniolisib
Severity: Minor
Cimetidine and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and could raise exposure to BCRP substrates. Cimetidine is only a weak or uncertain BCRP substrate, so any increase is likely small and of limited clinical importance.
What this interaction means in plain words
Cimetidine and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Leniolisib belongs to Miscellaneous.
Why it happens
Potential BCRP inhibition by leniolisib reducing efflux of cimetidine.
What to do
No dose change is needed; monitor for cimetidine adverse effects if clinical signs appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Cimetidine with Leniolisib?
MediHelp rates the interaction as minor. Cimetidine and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and could raise exposure to BCRP substrates. Cimetidine is only a weak or uncertain BCRP substrate, so any increase is likely small and of limited clinical importance.
How serious is the interaction between Cimetidine and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for cimetidine adverse effects if clinical signs appear.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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