Drug interactions
Cimetidine + Nalbuphine
Severity: Minor
Cimetidine and Nalbuphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nalbuphine is metabolized mainly by hepatic glucuronidation and other pathways, and there is no well-documented interaction with cimetidine. Additive sedation is possible only if clearance is reduced.
What this interaction means in plain words
Cimetidine and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Nalbuphine belongs to Musculoskeletal.
Why it happens
No established mechanism; a minor reduction in hepatic clearance by cimetidine is theoretical.
What to do
No routine action; monitor sedation and respiratory rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Cimetidine with Nalbuphine?
MediHelp rates the interaction as minor. Cimetidine and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nalbuphine is metabolized mainly by hepatic glucuronidation and other pathways, and there is no well-documented interaction with cimetidine. Additive sedation is possible only if clearance is reduced.
How serious is the interaction between Cimetidine and Nalbuphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor sedation and respiratory rate.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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