Drug interactions
Cimetidine + Oliceridine
Severity: Moderate
Cimetidine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may reduce the breakdown of oliceridine, raising its exposure and prolonging or intensifying opioid effects. This increases the risk of sedation and respiratory depression.
What this interaction means in plain words
Cimetidine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Oliceridine belongs to Musculoskeletal.
Why it happens
Cimetidine inhibits CYP2D6 and CYP3A4, which metabolize oliceridine.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine doses to effect, using less frequent dosing if needed. If cimetidine is stopped, reassess analgesia and watch for under-treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Cimetidine with Oliceridine?
MediHelp rates the interaction as moderate. Cimetidine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may reduce the breakdown of oliceridine, raising its exposure and prolonging or intensifying opioid effects. This increases the risk of sedation and respiratory depression.
How serious is the interaction between Cimetidine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine doses to effect, using less frequent dosing if needed. If cimetidine is stopped, reassess analgesia and watch for under-treatment.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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