Drug interactions
Cimetidine + Oxymorphone
Severity: Minor
Cimetidine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is expected to have little effect on oxymorphone, and any rise in exposure is likely to be small. Oxymorphone is cleared mainly by glucuronidation rather than CYP metabolism, so a meaningful interaction is theoretical.
What this interaction means in plain words
Cimetidine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Oxymorphone belongs to Musculoskeletal.
Why it happens
Cimetidine's CYP inhibition is expected to have little effect on oxymorphone, which is cleared mainly by UGT2B7 glucuronidation.
What to do
No dose change is usually needed; watch for excess sedation or respiratory depression when starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cimetidine with Oxymorphone?
MediHelp rates the interaction as minor. Cimetidine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is expected to have little effect on oxymorphone, and any rise in exposure is likely to be small. Oxymorphone is cleared mainly by glucuronidation rather than CYP metabolism, so a meaningful interaction is theoretical.
How serious is the interaction between Cimetidine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for excess sedation or respiratory depression when starting the combination.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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