Drug interactions
Cimetidine + Paclitaxel
Severity: Minor
Cimetidine and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine could increase paclitaxel exposure, but it is a weak inhibitor of the relevant pathways and clinical data suggest little effect. Any increase could heighten neutropenia and neuropathy.
What this interaction means in plain words
Cimetidine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Paclitaxel belongs to Oncology.
Why it happens
Theoretical weak inhibition of CYP3A4 and CYP2C8 metabolism of paclitaxel.
What to do
Monitor blood counts and neuropathy as per routine paclitaxel care; no dose adjustment is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Cimetidine with Paclitaxel?
MediHelp rates the interaction as minor. Cimetidine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine could increase paclitaxel exposure, but it is a weak inhibitor of the relevant pathways and clinical data suggest little effect. Any increase could heighten neutropenia and neuropathy.
How serious is the interaction between Cimetidine and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy as per routine paclitaxel care; no dose adjustment is usually required.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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