Drug interactions
Cimetidine + Pexidartinib
Severity: Moderate
Cimetidine and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib absorption falls with raised gastric pH, so acid-reducing drugs can lower its exposure and efficacy.
What this interaction means in plain words
Cimetidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Cimetidine raises gastric pH, reducing pexidartinib solubility and absorption.
What to do
Avoid H2 antagonists where possible; if needed, take pexidartinib at least 2 hours before or 10 hours after the H2 antagonist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Cimetidine with Pexidartinib?
MediHelp rates the interaction as moderate. Cimetidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib absorption falls with raised gastric pH, so acid-reducing drugs can lower its exposure and efficacy.
How serious is the interaction between Cimetidine and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 antagonists where possible; if needed, take pexidartinib at least 2 hours before or 10 hours after the H2 antagonist.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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