Drug interactions
Cimetidine + Sarecycline
Severity: Minor
Cimetidine and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-glycoprotein inhibitor and could marginally raise cimetidine exposure. Cimetidine has a wide therapeutic index, so clinical relevance is minimal.
What this interaction means in plain words
Cimetidine and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline increasing cimetidine absorption.
What to do
No dose adjustment is needed; be aware of cimetidine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Cimetidine with Sarecycline?
MediHelp rates the interaction as minor. Cimetidine and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-glycoprotein inhibitor and could marginally raise cimetidine exposure. Cimetidine has a wide therapeutic index, so clinical relevance is minimal.
How serious is the interaction between Cimetidine and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of cimetidine adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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