Drug interactions
Cimetidine + Secobarbital
Severity: Minor
Cimetidine and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower cimetidine concentrations, possibly weakening acid suppression. Cimetidine may in turn slightly raise barbiturate effects. Clinical relevance is limited and the data are sparse.
What this interaction means in plain words
Cimetidine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital may induce hepatic CYP enzymes, increasing cimetidine clearance, while cimetidine inhibits oxidative metabolism of some drugs.
What to do
No empirical dose change is needed; monitor for reduced control of acid symptoms and for excess sedation, adjusting either drug if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Cimetidine with Secobarbital?
MediHelp rates the interaction as minor. Cimetidine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates are enzyme inducers and may lower cimetidine concentrations, possibly weakening acid suppression. Cimetidine may in turn slightly raise barbiturate effects. Clinical relevance is limited and the data are sparse.
How serious is the interaction between Cimetidine and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for reduced control of acid symptoms and for excess sedation, adjusting either drug if needed.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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