Drug interactions
Cimetidine + Tinidazole
Severity: Minor
Cimetidine and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can reduce tinidazole clearance and prolong its half-life. Increased gastrointestinal and neurologic adverse effects are possible, though the effect is generally modest.
What this interaction means in plain words
Cimetidine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Tinidazole belongs to Anti Parasitic.
Why it happens
Cimetidine inhibits CYP3A4 and other hepatic enzymes involved in tinidazole metabolism.
What to do
No dose adjustment is typically needed for short courses; monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Cimetidine with Tinidazole?
MediHelp rates the interaction as minor. Cimetidine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine can reduce tinidazole clearance and prolong its half-life. Increased gastrointestinal and neurologic adverse effects are possible, though the effect is generally modest.
How serious is the interaction between Cimetidine and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is typically needed for short courses; monitor for adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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