Drug interactions
Cimetidine + Trilaciclib
Severity: Moderate
Cimetidine and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, the transporters responsible for renal secretion of cimetidine. Cimetidine concentrations may therefore increase, though the clinical effect is probably modest.
What this interaction means in plain words
Cimetidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2 and MATE-mediated tubular secretion of cimetidine, increasing its exposure.
What to do
Consider an alternative acid suppressant such as a proton pump inhibitor on trilaciclib treatment days, or monitor for cimetidine adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Cimetidine with Trilaciclib?
MediHelp rates the interaction as moderate. Cimetidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, the transporters responsible for renal secretion of cimetidine. Cimetidine concentrations may therefore increase, though the clinical effect is probably modest.
How serious is the interaction between Cimetidine and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative acid suppressant such as a proton pump inhibitor on trilaciclib treatment days, or monitor for cimetidine adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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