Drug interactions
Cimetidine + Vinblastine
Severity: Moderate
Cimetidine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase vinblastine exposure and its toxicity, such as myelosuppression and neurotoxicity. Evidence is limited and based on mechanistic prediction.
What this interaction means in plain words
Cimetidine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Vinblastine belongs to Oncology.
Why it happens
Cimetidine inhibits CYP3A4 metabolism of vinblastine.
What to do
Prefer famotidine or another acid suppressant lacking CYP inhibition during chemotherapy, and monitor blood counts and neurotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Cimetidine with Vinblastine?
MediHelp rates the interaction as moderate. Cimetidine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase vinblastine exposure and its toxicity, such as myelosuppression and neurotoxicity. Evidence is limited and based on mechanistic prediction.
How serious is the interaction between Cimetidine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer famotidine or another acid suppressant lacking CYP inhibition during chemotherapy, and monitor blood counts and neurotoxicity.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
