Drug interactions
Cimetidine + Ziprasidone
Severity: Minor
Cimetidine and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine had little effect on ziprasidone exposure in pharmacokinetic studies, because CYP3A4 is only a minor route of ziprasidone clearance. A clinically meaningful change in ziprasidone levels or QT effect is not expected.
What this interaction means in plain words
Cimetidine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by cimetidine, which has limited effect since ziprasidone is mainly cleared by aldehyde oxidase.
What to do
No dose adjustment is usually needed. Follow routine ECG and electrolyte monitoring for ziprasidone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Cimetidine with Ziprasidone?
MediHelp rates the interaction as minor. Cimetidine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine had little effect on ziprasidone exposure in pharmacokinetic studies, because CYP3A4 is only a minor route of ziprasidone clearance. A clinically meaningful change in ziprasidone levels or QT effect is not expected.
How serious is the interaction between Cimetidine and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Follow routine ECG and electrolyte monitoring for ziprasidone.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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