Drug interactions
Cinacalcet + Erythromycin
Severity: Moderate
Cinacalcet and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase cinacalcet exposure, increasing the risk of hypocalcemia and gastrointestinal effects such as nausea and vomiting.
What this interaction means in plain words
Cinacalcet and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4, one of the enzymes metabolizing cinacalcet.
What to do
Monitor serum calcium and PTH during and after erythromycin therapy, and adjust the cinacalcet dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Erythromycin?
MediHelp rates the interaction as moderate. Cinacalcet and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase cinacalcet exposure, increasing the risk of hypocalcemia and gastrointestinal effects such as nausea and vomiting.
How serious is the interaction between Cinacalcet and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH during and after erythromycin therapy, and adjust the cinacalcet dose as needed.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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