Drug interactions
Cinacalcet + Lofexidine
Severity: Moderate
Cinacalcet and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor, and lofexidine is cleared in part by CYP2D6. Co-administration may raise lofexidine exposure and increase hypotension, orthostasis, bradycardia and sedation.
What this interaction means in plain words
Cinacalcet and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Lofexidine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of lofexidine by cinacalcet.
What to do
Monitor blood pressure and heart rate, particularly for orthostasis and bradycardia. Consider reducing the lofexidine dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Cinacalcet with Lofexidine?
MediHelp rates the interaction as moderate. Cinacalcet and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a strong CYP2D6 inhibitor, and lofexidine is cleared in part by CYP2D6. Co-administration may raise lofexidine exposure and increase hypotension, orthostasis, bradycardia and sedation.
How serious is the interaction between Cinacalcet and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly for orthostasis and bradycardia. Consider reducing the lofexidine dose if symptoms occur.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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