Drug interactions
Cinacalcet + Miconazole
Severity: Minor
Cinacalcet and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is cleared partly by CYP3A4, and miconazole can inhibit this enzyme after vaginal absorption. Cinacalcet exposure may rise and lower serum calcium more than intended. The effect is likely small with short vaginal courses.
What this interaction means in plain words
Cinacalcet and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing cinacalcet clearance.
What to do
No routine change is needed for a short vaginal course. Check serum calcium and PTH if the patient has symptoms of hypocalcemia or uses miconazole repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinacalcet and Miconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Miconazole
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Miconazole?
MediHelp rates the interaction as minor. Cinacalcet and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is cleared partly by CYP3A4, and miconazole can inhibit this enzyme after vaginal absorption. Cinacalcet exposure may rise and lower serum calcium more than intended. The effect is likely small with short vaginal courses.
How serious is the interaction between Cinacalcet and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for a short vaginal course. Check serum calcium and PTH if the patient has symptoms of hypocalcemia or uses miconazole repeatedly.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
