Drug interactions
Cinacalcet + Nifedipine
Severity: Minor
Cinacalcet and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is metabolized by several CYP enzymes including CYP3A4, so nifedipine is unlikely to change its exposure meaningfully. No clinically relevant interaction is expected.
What this interaction means in plain words
Cinacalcet and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Nifedipine belongs to Cardiovascular.
Why it happens
Theoretical weak CYP3A4 inhibition with multiple alternative clearance pathways for cinacalcet.
What to do
No action is needed beyond routine monitoring of serum calcium and PTH.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Nifedipine?
MediHelp rates the interaction as minor. Cinacalcet and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinacalcet is metabolized by several CYP enzymes including CYP3A4, so nifedipine is unlikely to change its exposure meaningfully. No clinically relevant interaction is expected.
How serious is the interaction between Cinacalcet and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring of serum calcium and PTH.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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