Drug interactions
Cinacalcet + Nilotinib
Severity: Moderate
Cinacalcet and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and CYP2D6 and may raise cinacalcet exposure, increasing hypocalcemia risk. Both drugs may also affect QT interval, and hypocalcemia further increases that risk.
What this interaction means in plain words
Cinacalcet and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4 and CYP2D6 metabolism of cinacalcet, with additive QT risk.
What to do
Monitor serum calcium and ECG. Adjust cinacalcet dose to calcium levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Nilotinib?
MediHelp rates the interaction as moderate. Cinacalcet and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and CYP2D6 and may raise cinacalcet exposure, increasing hypocalcemia risk. Both drugs may also affect QT interval, and hypocalcemia further increases that risk.
How serious is the interaction between Cinacalcet and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and ECG. Adjust cinacalcet dose to calcium levels.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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