Drug interactions
Cinacalcet + Oxcarbazepine
Severity: Minor
Cinacalcet and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce cinacalcet exposure by inducing CYP3A4, which contributes to its metabolism. Parathyroid hormone and calcium control may be affected.
What this interaction means in plain words
Cinacalcet and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Mild CYP3A4 induction by oxcarbazepine increases cinacalcet clearance.
What to do
Monitor serum calcium and PTH and adjust the cinacalcet dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Oxcarbazepine?
MediHelp rates the interaction as minor. Cinacalcet and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine may reduce cinacalcet exposure by inducing CYP3A4, which contributes to its metabolism. Parathyroid hormone and calcium control may be affected.
How serious is the interaction between Cinacalcet and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and adjust the cinacalcet dose accordingly.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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