Drug interactions
Cinacalcet + Rufinamide
Severity: Minor
Cinacalcet and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and might slightly lower cinacalcet exposure. Clinical impact is expected to be small.
What this interaction means in plain words
Cinacalcet and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cinacalcet belongs to Miscellaneous; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 modestly increases cinacalcet clearance.
What to do
Check serum calcium and PTH at the next routine monitoring after rufinamide is started or stopped. Adjust the cinacalcet dose only if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Cinacalcet with Rufinamide?
MediHelp rates the interaction as minor. Cinacalcet and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and might slightly lower cinacalcet exposure. Clinical impact is expected to be small.
How serious is the interaction between Cinacalcet and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium and PTH at the next routine monitoring after rufinamide is started or stopped. Adjust the cinacalcet dose only if response changes.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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