Drug interactions
Cinnarizine + Dimenhydrinate
Severity: Moderate
Cinnarizine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antihistamines used for vertigo and motion sickness, and both cause drowsiness. Together they increase sedation and anticholinergic effects, and cinnarizine may also cause extrapyramidal symptoms, especially in older adults.
What this interaction means in plain words
Cinnarizine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinnarizine belongs to Respiratory; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive H1-receptor and muscarinic blockade with CNS depression.
What to do
Avoid using both and choose one agent. If combined, monitor for oversedation, falls and movement disorders in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cinnarizine and Dimenhydrinate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dimenhydrinate
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Cinnarizine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Cinnarizine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antihistamines used for vertigo and motion sickness, and both cause drowsiness. Together they increase sedation and anticholinergic effects, and cinnarizine may also cause extrapyramidal symptoms, especially in older adults.
How serious is the interaction between Cinnarizine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both and choose one agent. If combined, monitor for oversedation, falls and movement disorders in older patients.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
